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德克薩斯大學開發出最小最快分子馬達輸送藥物

放大字體  縮小字體 發布日期:2015-07-17  瀏覽次數:585
核心提示:2014年5月26日訊 /生物谷BIOON/ --長期以來,在納米載藥系統的研究中,載藥系統的輸送速度是研究人員考量的重要參數。基于這一想
 2014年5月26日訊 /生物谷BIOON/ --長期以來,在納米載藥系統的研究中,載藥系統的輸送速度是研究人員考量的重要參數。基于這一想法,科學家開發出一系列納米機器人。現在來自美國德克薩斯大學的研究人員開發出一種被認為可能是目前最小、轉運速度最快的分子馬達,為人類開發新一代納米機器人和納米載藥系統提供了新的可能性。根據該團隊發表在Nature Communications上的結果顯示,這些分子馬達可以持續運行長達15h,是目前已知在該尺寸分子馬達上最快的。研究熱源利用這種分子馬達包載胰島素和抗癌藥物發現,這種分子馬達旋轉越快,則藥物分子釋放越快。下一步工作人員希望考察這種納米載藥系統與細胞的相互作用情況以及相關藥效學評價。(生物谷Bioon.com)

詳細英文報道:

Mobility is an important function of any drug-delivering robot--even a well-designed machine that ultimately can't get wher it's needed serves little to no purpose. To this end, researchers have developed a wide range of innovative devices from microrockets to DNA propellers tosperm-driven robots.

Now, researchers at the University of Texas at Austin have built what promises to be the smallest, fastest and longest running synthetic motor yet made, according to a report from the university. And although they haven't incorporated them into delivery devices currently, these motors could one day find their way into the smallest nanorobots still in development.

The mechanical engineers created a three-part nanomotor that uses biochemicals to pump itself (and any vehicle attached to it) through liquids, the team published in the journal Nature Communications. And with these mechanisms in place, the motor can run for up to 15 hours at 18,000 rotations per minute, much faster than any others of its size.

For drug delivery, the team envisions its nanomotor carrying vehicles for insulin or cancer drugs. To test this capability, they coated the motor with chemicals to mimic the release of drugs, and the faster the motor spun, the faster it released the chemicals.

"We were able to establish and control the molecule release rate by mechanical rotation, which means our nanomotor is the first of its kind for controlling the release of drugs from the surface of nanoparticles," lead author Donglei Fan said in a statement. "We believe it will help advance the study of drug delivery and cell-to-cell communications."

The next step is to use the minuscule motors near a live cell to see how they interact and to measure the release of chemicals in a treatment scenario.

 
 
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